TV's most unlikable protagonists, but underneath his troubled exterior, he cared about a small handful of other characters. His friendship with Wilson and grudging respect for Thirteen are some of House's highlights, but his relationship with Lisa Cuddy has been controversial.

Of all the characters in House, Cuddy is the only one who can forcefully affect House's actions, as she is his boss. That said, while House and Cuddy regularly butted heads, which often had hilarious results, she tended to allow him to work in his own unique way. Part of the constant conflict between the two characters was their attraction to each other, which virtually all the other characters could see, except, perhaps, them. Unfortunately for viewers, House was on a downward trajectory after the relationship became official in one of House's best episodes.

"Help Me" Was The Start Of House And Cuddy's Relationship

"Help Me" Was One Of House's Best Episodes

"Help Me" was House's season 6 finale and marked the beginning of House and Cuddy's romantic relationship after years of flirting-filled conflict. The outing was harrowing, as House and his team ed a search and rescue operation. House is dealing with painful memories triggered by a patient's injury while trying to ignore his feelings for Cuddy, who has just got engaged. The season ends with a kiss between the two, which was one of the show's best House and Cuddy moments and a perfect counterpart to the episode, which showed the worst moments of a medic's career.

House has often been criticized for being an unrealistic representation of the medical profession.

"Help Me" was one of House's best episodes as it was almost equally filled with horror and hope. While House has often been criticized for being an unrealistic representation of the medical profession, "Help Me" showed a realistic element of the medical world. Despite the combined expertise of his team, House discovered that their patient would have died no matter what they did, as she had a complication due to amputating her leg. The aftermath is almost equally painful, with House struggling with his addiction, but when Cuddy arrives, the series ends on a hopeful note.

House And Cuddy Were Great Together (But Their Relationship Ruined The Show)

House And Dominika Could Have Had A More Long-Lasting Relationship On The Show

House and Cuddy were one of the best couples in House, with the two complementing each other while surprising themselves. House had little regard for rules, so starting a relationship with his boss was not out of character for him (whereas starting a relationship at all was.) On the other hand, Cuddy was looking for love, but she likely could not have foreseen falling in love with House. The actors had undeniable chemistry, and Cuddy was able to keep House in check, excitingly changing the show's dynamic. However, the relationship was doomed when Cuddy was written out of House.

Dominika was originally introduced in season 7 as part of House's petty revenge after he and Cuddy broke up. However, though the two appeared to have nothing in common, House and Dominika got on well, even developing feelings for each other after their sham marriage. Their attempts to convince the authorities that they are genuinely in love provide some of the funniest moments in House. Dominika is smart, a good problem-solver, and genuinely kind, making her an amazing House character who deserved better after House hid her immigration permit to keep her around.

House Was Bound To Have A Bittersweet Ending After Cuddy And House Broke Up

Cuddy Is Unlikely To Return For A House Reboot

With Cuddy gone and House's Vicodin addiction continuing, things only went south for him. Though House and Cuddy were good together, the most important relationship in House was that of House and Wilson. Many reviewers predicted that the show's ending would involve powerful emotional moments between the two best friends, but Wilson's shock cancer diagnosis packed an even greater punch without Cuddy. Faced with the prospect of losing his best friend too, it was a good decision for House to end before Wilson died, and the finale was as positive as the show could have, given the circumstances.

Lisa Edelstein won the People's Choice Award for Favorite TV Drama Actress for her portrayal of Dr. Lisa Cuddy in House.

While there are many opportunities for Hugh Laurie's character to return in a House revival, it is unlikely that Cuddy would also return. After Lisa Edelstein won critical acclaim for her role as Cuddy, she moved on to other projects and has no regrets about deciding not to return for the finale. Edelstein told Digital Spy that she didn't feel that Cuddy and House were meant to be, saying "I don't think that show was about happy endings." House was an incredibly successful drama, but even a reboot is unlikely to bring House and Cuddy back together.

Source: Digital Spy